Phenytoin potentiates interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts
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Interleukin-4 Suppresses Interleukin-1-Induced Expression of Matrix Metalloproteinase-3 in Human Gingival Fibroblasts
OBJECTIVE—In periodontitis, matrix metalloproteinase 3 (MMP-3, stromelysin 1) is present at increased levels in active disease sites compared to inactive or healthy sites, and the levels are correlated with clinical parameters and associated with progression of the disease. Interleukin 4 (IL-4) has been shown in other systems to suppress interleukin-1 (IL-1) induced expression of MMP-3, but thi...
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17B-ol-3-one, 5( 10)-estren17/3-ol-3-one, an isomer each of 5-estrane-3,17-diol and estradiene-3,17-diol and two isomers each of S( 10)-estren-3-ol-17-one and S( l0)-estrene3,17-diol were identified. None of these steroids was detected in the blank incubated samples. In the blank phenolic fractions traces of oestrone and oestradiol-17P were present. In the post-incubation extracts a definite in...
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Gingival overgrowth is a common adverse effect of therapy with Phenytoin, having important medical and cosmetic implications. Poor periodontal hygiene is an important risk factor for severity of Phenytoin-induced gingival overgrowth (PIGO), which is a time-dependent process. There is complex interplay of altered fibroblast biology, connective tissue turnover, inflammatory processes, and growth ...
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To cite: Chacko LN, Abraham S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204670 DESCRIPTION Gingival overgrowth occurs as a side effect of some systemic medications. It is now well established that phenytoin is one such agent. It has multiple therapeutic indications ranging from convulsive disorders and neuralgias to cardiac arrhythmia. The incidence rat...
متن کاملNonsurgical Management of Phenytoin-induced Gingival Hyperplasia.
INTRODUCTION The aim of this report is to present a severe case of phenytoin (PHT)-induced gingival hyperplasia in a Saudi patient. MATERIALS AND METHODS A 12-year-old male epileptic patient, undergoing PHT therapy, was diagnosed clinically with severe gingival hyperplasia. His treatment consisted meticulous oral care and weekly professional prophylaxis. The patient was advised oral folic aci...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1992
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1992.tb14377.x